2026-02-12 — 7 min
Morning person or night owl? The answer lies in your genes
🇬🇷 Διαβάστε στα Ελληνικά
Why do some people wake up full of energy at 6:00 AM, while others can barely open their eyes before 10:00? This difference isn’t just a matter of habit or discipline. It’s a biological trait linked to our internal clock – and as science shows, our genes play a crucial role in shaping it.
Welcome to the fascinating world of chronotypes, circadian rhythms, and nutrigenetics – where the time you wake up, when you feel hungry, and even how your body processes food may be influenced by your DNA.
What is a chronotype?
A chronotype is your body’s natural tendency to be more active and alert during certain hours of the day. This isn’t just about personal preference or routine – it’s a biological characteristic regulated by your circadian clock, a mechanism in the brain that syncs with the natural light-dark cycle.
There are three main chronotypes:
Morning type: Performs best early in the day, tends to go to bed early.
Evening type: Becomes more alert later in the day, stays awake until late at night.
Intermediate type: The majority of people, with balanced activity levels throughout the day.
Behind this natural “time preference” lies our genetic makeup – with one key player being the CLOCK gene.
The CLOCK gene – the timekeeper of your biological rhythm
At the heart of this process is the CLOCK gene (Circadian Locomotor Output Cycles Kaput). This gene regulates your sleep-wake cycle, influences hormone production such as cortisol and melatonin, and even affects your body temperature, appetite, and how efficiently you use energy during the day.
In addition, CLOCK interacts with other genes that control metabolism, influencing how your body processes nutrients throughout the day. As a result, two people following similar diets may respond very differently when it comes to weight management or blood sugar control, simply due to variations in this gene.
How chronotype and nutrition are connected
Nutrigenetics examines how our genes affect our metabolic response to food. In the case of CLOCK, meal timing can have different outcomes depending on your genetic profile:
Certain CLOCK variants are linked to late-night cravings for fatty foods.
Others are associated with greater difficulty losing weight when main meals are eaten later in the day.
Research suggests that CLOCK can also influence insulin release, making the body less efficient at managing glucose in the evening.
In simple terms, this gene doesn’t just determine whether you’re a “morning person” or a “night owl” – it also affects the times of day when your body is best equipped to process food and energy.
Why does knowing your chronotype matter?
Understanding your chronotype can impact:
Performance and focus: Helping you manage your time and energy more effectively.
Mood and mental health: Reducing “social jet lag,” when social demands conflict with your natural rhythm.
Metabolism and weight: Since meal timing influences whether energy is used immediately or stored as fat.
Can you change your chronotype?
Many night owls try to “fix” their sleep schedule to become morning types, but chronotype is largely genetically determined. It can shift slightly (by 1–2 hours) with strategies such as:
Exposure to natural light in the morning,
Reducing screen time and bright lights at night,
Maintaining consistent sleep and meal schedules.
However, fully transforming a night owl into a morning person is rare and often stressful for the body, as it goes against its natural biology. The most effective approach is to understand your own rhythm and adapt your lifestyle to work with it – not against it.
How we can help
At our center, we offer a nutrigenetic DNA test that analyzes, among other factors, your CLOCK gene. This allows us to understand whether your body functions best in the morning or evening and to tailor your nutrition and daily routine to your true biological needs – helping you achieve more energy, better sleep, and balance in your everyday life.
References
Jones, S.E., Lane, J.M., Wood, A.R. et al. Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms. Nat Commun 10, 343 (2019). https://doi.org/10.1038/s41467-018-08259-7
Corella, D., Asensio, E. M., Coltell, O., Sorlí, J. V., Estruch, R., Martínez-González, M. Á., Salas-Salvadó, J., Castañer, O., Arós, F., Lapetra, J., Serra-Majem, L., Gómez-Gracia, E., Ortega-Azorín, C., Fiol, M., Espino, J. D., Díaz-López, A., Fitó, M., Ros, E., & Ordovás, J. M. (2016). CLOCK gene variation is associated with incidence of type-2 diabetes and cardiovascular diseases in type-2 diabetic subjects: dietary modulation in the PREDIMED randomized trial. Cardiovascular diabetology, 15, 4. https://doi.org/10.1186/s12933-015-0327-8
Özata Uyar, G., Yıldıran, H., Teker-Düztaş, D., Dalgic, B., Karakaş, N. M., Çamurdan, M. O., Ergin, F. B., & Ezgü, F. S. (2024). Association between CLOCK gene polymorphisms with circadian rhythm, chrononutrition, dietary intake, and metabolic parameters in adolescents. Frontiers in public health, 12, 1435460. https://doi.org/10.3389/fpubh.2024.1435460
Rijo-Ferreira, F., & Takahashi, J. S. (2019). Genomics of circadian rhythms in health and disease. Genome medicine, 11(1), 82. https://doi.org/10.1186/s13073-019-0704-0
Torrego-Ellacuría, M., Barabash, A., Matía-Martín, P., Sánchez-Pernaute, A., Torres, A. J., Calle-Pascual, A. L., & Rubio-Herrera, M. A. (2022). Influence of CLOCK Gene Variants on Weight Response after Bariatric Surgery. Nutrients, 14(17), 3472. https://doi.org/10.3390/nu14173472
Schrader, L. A., Ronnekleiv-Kelly, S. M., Hogenesch, J. B., Bradfield, C. A., & Malecki, K. M. (2024). Circadian disruption, clock genes, and metabolic health. The Journal of clinical investigation, 134(14), e170998. https://doi.org/10.1172/JCI170998
Montaruli, A., Castelli, L., Mulè, A., Scurati, R., Esposito, F., Galasso, L., & Roveda, E. (2021). Biological Rhythm and Chronotype: New Perspectives in Health. Biomolecules, 11(4), 487. https://doi.org/10.3390/biom11040487
Gentry, N. W., Ashbrook, L. H., Fu, Y. H., & Ptáček, L. J. (2021). Human circadian variations. The Journal of clinical investigation, 131(16), e148282. https://doi.org/10.1172/JCI148282
van der Merwe, C., Münch, M., & Kruger, R. (2022). Chronotype Differences in Body Composition, Dietary Intake and Eating Behavior Outcomes: A Scoping Systematic Review. Advances in nutrition (Bethesda, Md.), 13(6), 2357–2405. https://doi.org/10.1093/advances/nmac093
Zhang, R., Cai, X., Lin, C., Yang, W., Lv, F., Wu, J., & Ji, L. (2022). The association between metabolic parameters and evening chronotype and social jetlag in non-shift workers: A meta-analysis. Frontiers in endocrinology, 13, 1008820. https://doi.org/10.3389/fendo.2022.1008820
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